Author

J. E. Himes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:flow cytometry· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. J. Wisdom· 3 shared D. G. Kirsch· 3 shared L. Luo· 3 shared Y. M. Mowery· 3 shared Y. Ma· 3 shared C. L. Kent· 2 shared N. Williams· 2 shared A. Kumar· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

A. J. Wisdom

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Author profile →

4 papers

Recent·Most cited

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

C. Su, C. L. Kent, M. Pierpoint, W. Floyd, L. Luo, N. T. Williams, Y. Ma, B. Peng, A. L. Lazarides, A. Subramanian, J. E. Himes, V. M. Perez, R. D. Hernansaiz-Ballesteros, K. E. Roche, J. L. Modliszewski, , D. G. Kirsch

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

bioRxiv · Jan 3, 2024 · PreprintCancer Biology

Both CD8 and CD4 T cells contribute to immunosurveillance preventing the development of neoantigen-expressing autochthonous sarcomas

J. E. Himes, A. J. Wisdom, L. Wang, S. J. Shepard, A. R. Daniel, N. Williams, L. Luo, Y. Ma, Y. M. Mowery, D. G. Kirsch

This study develops an autochthonous murine sarcoma model and shows that both CD8 and CD4 T cells are required for immunosurveillance against neoantigen-expressing tumors.

bioRxiv · Apr 4, 2023 · PreprintCancer Biology

A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

A. J. Wisdom, Y. M. Mowery, C. S. Hong, X. Qin, D. Zhang, J. E. Himes, L. Chen, H. Fradin, E. S. Muise, E. S. Xu, D. J. Carpenter, C. L. Kent, K. S. Smythe, N. Williams, L. Luo, , D. G. Kirsch

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

bioRxiv · Mar 11, 2020Cancer Biology

Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys.

J. E. Himes, R. Goswami, R. J. Mangan, A. Kumar, T. L. Jeffries, J. A. Eudailey, H. Heimsath, Q. N. Nguyen, J. Pollara, C. LaBranche, M. Chen, N. A. Vandergrift, J. W. Peacock, F. Schiro, C. Midkiff, , S. R. Permar

This study shows that a tri-mAb cocktail of HIV envelope-specific antibodies reduces SHIV acquisition and viral loads in infant rhesus monkeys.

bioRxiv · Jun 3, 2017Immunology