MicrobiologybioRxiv
Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins
K. Pheasant, C. S. Möller-Levet, J. Jones…·G. Elliott
This study reveals that HSV1's vhs endoribonuclease, along with cofactors VP22 and VP16, coordinates nuclear-cytoplasmic compartmentalization of the infected cell transcriptome to regulate late protein translation.
DOI 10.1371/journal.ppat.1007331