J. Jones

Immunogenicity of autologous and allogeneic human primary cholangiocyte organoids

The immune response to human primary cholangiocyte organoids is ameliorated by donor-recipient HLA matching.

Structural characterization of two full length γδTCR/CD3 complexes

This study reports cryoEM structures of two full-length γδ TCR/CD3 complexes, revealing similarities to β TCRs but with highly mobile extracellular domains and a dimeric assembly in one complex.

Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling

This study shows that circadian rhythm disruption causes abnormal mammary morphology and aggressive basal tumorigenesis by increasing LILRB4 signaling and creating an immunosuppressive tumor microenvironment.

Seedless: On-the-fly pulse calculation for NMR experiments

Seedless calculates NMR pulses on-the-fly to improve signal-to-noise by compensating for RF inhomogeneity and chemical shift effects.

Insecticidal roof barriers mounted on untreated bednets can be as effective against Anopheles gambiae s.l. as insecticidal bednets

This study evaluates barrier bednets (BBnets) against Anopheles gambiae s.l., finding that BBnets with insecticidal barriers can be as effective as standard insecticidal bednets.

Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon response

This study shows that STING is required for TLR8-induced IFN production in human monocytes and reveals a new crosstalk mechanism between cytosolic and endosomal innate immune receptors.

Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming

This study identifies how Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis promote oncogenic changes in colorectal cancer by affecting epithelial cells and immune responses.

Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM

The paper reports cryoEM structures of TCR-CD3 complexes and pMHC ligands, revealing structural insights into TCR recognition of cancer antigens.

A Novel Restraint Device to Improve Safety and Efficacy of Blood Collection During Non-Terminal Sampling of Bats

This paper introduces a bat restraint device to improve safety and efficiency of blood collection from bats, showing positive user feedback and no adverse effects.

Oncogenic c-Myc activity increases tolerance to proteotoxic and genotoxic stress through regulation of HSF1

This study shows c-Myc increases cellular tolerance to proteotoxic and genotoxic stress by upregulating HSF1, which supports cell survival under c-Myc-induced stress conditions.

Bio-inspired artificial printed bioelectronic cardio-3D-cellular constructs

This paper develops conductive bioinks for 3D bioprinting that enhance cardiomyocyte contractility through electrical stimulation and biomimetic structures.

Intestinal Bacteroides Modulates Systemic Inflammation and the Microbial Ecology in a Mouse Model of CF: Evidence for Propionate and other Short Chain Fatty Acids Reducing Systemic Inflammatory Cytokines

This study shows that Bacteroides in CF patients reduces systemic inflammation via propionate and alters microbial ecology in a mouse model of CF.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

Swine H1N1 influenza virus variants with enhanced polymerase activity and HA stability promote airborne transmission in ferrets

Conservation of endangered galaxiid fishes in the Falkland Islands requires urgent action on invasive brown trout

The paper assesses the impact of invasive brown trout on native galaxiid fishes in the Falkland Islands, finding high establishment success and predicting near-complete invasion within 70 years.

Cell-to-cell transmission of HSV1 in human keratinocytes in the absence of the major entry receptor, nectin1

This study shows HSV1 can spread between human keratinocytes via direct cell-to-cell transmission even when the primary receptor nectin1 is absent.

Pre-existing immunity provides a barrier to airborne transmission of influenza viruses

The paper shows that pre-existing non-neutralizing immunity in ferrets blocks airborne transmission of seasonal influenza viruses.

The RAG1 Ubiquitin Ligase Domain Enhances Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity

This study shows that the RAG1 ubiquitin ligase domain enhances TCR gene assembly and selection, reducing autoimmune risk in mice.

The Rpi-mcq1 resistance gene family recognizes Avr2 of Phytophthora infestans but is distinct from R2

The paper identifies a new family of Rpi genes in Solanum species that recognize the same effector AVR2 as the R2 gene family, showing two distinct R protein families can target the same pathogen effector.

Screening of Cultivars for Tissue Culture Response and Establishment of Genetic Transformation in a High-yielding and Disease-resistant Cultivar of Theobroma cacao

The paper establishes tissue culture and genetic transformation methods for a high-yielding, disease-resistant Theobroma cacao cultivar and identifies factors improving T-DNA delivery and somatic embryogenesis.

A minimal 3D model of mosquito flight behavior around the human baited bed net

This paper develops a 3D model simulating mosquito flight behavior around human-baited bed nets, showing how net presence and bait orientation affect flight patterns and contact distribution.

Bee visitation and fruit quality in berries under protected cropping vary along the length of polytunnels

The paper examines how bee visitation and fruit quality in berries vary along the length of polytunnels, finding higher pollinator activity and better fruit quality at tunnel ends.

Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins

This study reveals that HSV1's vhs endoribonuclease, along with cofactors VP22 and VP16, coordinates nuclear-cytoplasmic compartmentalization of the infected cell transcriptome to regulate late protein translation.

Demographic determinants of biometric heritability

This paper examines how demographic factors like selection and growth influence biometric heritability in long-lived species.