J. Breuer

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection

This study examines the genetic effects of effective and suboptimal dosing of mutagenic drugs on SARS-CoV-2 in hamsters, finding dose-dependent mutational load and no drug resistance.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks

This study shows that incorporating within-host genetic diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks.

The combined treatment of Molnupiravir and Favipiravir results in a marked potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

This study shows that combining Molnupiravir and Favipiravir significantly enhances antiviral efficacy against SARS-CoV-2 in hamsters, reducing viral titers by 4.5 log10 and eliminating detectable virus in 60% of treated animals.

Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency

This study identifies VLT-ORF63 fusion transcripts in VZV-infected neurons, showing they drive lytic gene expression during reactivation from latency.

Decoding the architecture of the varicella-zoster virus transcriptome

This study reannotates the VZV transcriptome using RNA sequencing to identify 136 polyadenylated RNAs, including ORFs, non-canonical ORFs, ORF fusions, and ncRNAs, revealing unexpected kinetic classes of viral transcripts.

A large effective population size for within-host influenza virus infection

The paper estimates the effective population size of influenza virus within-host infections, finding it large enough that genetic drift has minimal impact, with positive selection limited by infection duration.

β-L-1- uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity

This study shows L-BHDU's effectiveness against VZV and HSV-1 relies on thymidine kinase activity, as resistant strains have mutations in TK that impair drug phosphorylation.

Whole genome sequencing of Herpes Simplex Virus 1 directly from human cerebrospinal fluid reveals selective constraints in neurotropic viruses.

This study uses whole genome sequencing of HSV-1 from CSF and skin lesions to identify selective constraints and recombination patterns in neurotropic viruses.

In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix

The paper identifies a novel protease inhibitor resistance signature in HIV-1 matrix through genotypic and phenotypic analysis of patients failing PI therapy.

Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins

This study reveals that HSV1's vhs endoribonuclease, along with cofactors VP22 and VP16, coordinates nuclear-cytoplasmic compartmentalization of the infected cell transcriptome to regulate late protein translation.