Author

G. Chi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. C. W. Pike· 2 shared D. B. Sauer· 2 shared E. P. Carpenter· 2 shared X. Wang· 2 shared A. Evans· 1 shared A. M. Egloff· 1 shared A. Pautsch· 1 shared A. Quigley· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

A. C. W. Pike

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5 papers

Recent·Most cited

Structural basis of the mechanism and inhibition of a human ceramide synthase

T. C. Pascoa, A. C. W. Pike, C. S. Tautermann, G. Chi, M. Traub, A. Quigley, R. Chalk, S. Stefanic, S. Thamm, A. Pautsch, E. P. Carpenter, G. Schnapp, D. B. Sauer

This study determines the structural mechanism of CerS6, a ceramide synthase, using cryo-EM and biochemical analysis, revealing a ping-pong reaction mechanism and insights into fumonisin B1 inhibition.

bioRxiv · Dec 2, 2023Biochemistry

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

H. Z. Li, A. C. W. Pike, G. Chi, J. S. Hansen, S. G. Lee, K. E. J. Rodstrom, S. R. Bushell, D. Speedman, A. Evans, D. Wang, D. He, L. Shrestha, C. Nasrallah, N. A. Burgess-Brown, T. R. Dafforn, , D. B. Sauer

The paper determines the structure of the SIT1 proline transporter complexed with ACE2 using cryo-EM, revealing substrate specificity and structural changes related to transport and a disease-causing mutation.

bioRxiv · May 17, 2023Biophysics

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

M. S. Taylor, W. Connie, P. C. Fridy, S. J. Zhang, Y. Senussi, J. C. Wolters, W.-C. Cheng, J. Heaps, B. D. Miller, K. Mori, L. Cohen, H. Jiang, K. R. Molloy, B. L. Norden, B. T. Chait, , O. H. Yilmaz

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

bioRxiv · Jan 25, 2023 · PreprintCancer Biology

Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A

C. Zhang, T. Fang, X. Wang, L. Shi, B. Zhan, N. Hou, S. Liu, M. Bao, G. Chi

This study identifies alnustone as a drug that inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A, reducing biofilm formation and protecting against infection.

bioRxiv · Mar 7, 2022Microbiology

Snapshots of actin and tubulin folding inside the TRiC chaperonin

J. J. Kelly, D. Tranter, E. Pardon, G. Chi, H. Kramer, K. Knee, J. Janz, J. Steyaert, C. Bulawa, V. Paavilainen, J. Huiskonen, W. Yue

The paper captures structural snapshots of actin and tubulin folding within the TRiC chaperonin using cryo-EM, revealing how substrates interact with the chamber during folding.

bioRxiv · Mar 26, 2021Biochemistry