Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice
G. M. Olivarria, Y. Cheng, C. Pachow, L. A. Hohsfield, C. Smith-Geater, R. Miramontes, J. Wu, M. S. Burns, K. I. Tsourmas, J. Stocksdale, C. Manlapaz, S. Furman, W. H. Yong, J. Teijaro, R. A. Edwards, , T. Lane
This study shows SARS-CoV-2 infects neurons in the CNS of K18-hACE2 mice, with microglia not restricting viral replication but contributing to inflammation.
bioRxiv · Nov 15, 2021Microbiology