R. A. Edwards

Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

This paper describes a multi-epitope vaccine that provides cross-protection against multiple SARS-CoV-2 variants by inducing functional T cell responses.

Temperate gut phages are prevalent, diverse, and predominantly inactive

The paper characterizes active temperate gut phages from bacterial isolates, finding most are inactive and their induction is complex and context-dependent.

Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

This study shows RAGE-Ig reduces viral replication and inflammation in multiple SARS-CoV-2 variants using animal models and human cells.

Towards the biogeography of butyrate-producing bacteria

This study examines the global biogeography of butyrate-producing bacteria and identifies key environmental factors influencing their distribution.

High Frequencies of PD-1+TIM3+TIGIT+CTLA4+ Functionally Exhausted SARS-CoV-2-Specific CD4+ and CD8+ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice

This study shows SARS-CoV-2 infects neurons in the CNS of K18-hACE2 mice, with microglia not restricting viral replication but contributing to inflammation.

Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection

This study examines immune changes in pregnant women with mild SARS-CoV-2 infection, finding altered immune responses in blood and decidua that may impact fetal development.

Predicting COVID-19 Severity with a Specific Nucleocapsid Antibody plus Disease Risk Factor Score

This paper identifies an antibody epitope and a risk score to predict severe COVID-19 outcomes with high specificity.

Genome-Wide Asymptomatic B-Cell, CD4+ and CD8+ T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus Vaccines

The paper identifies conserved B-cell and T-cell epitopes across multiple Coronaviruses to inform the development of a pan-Coronavirus vaccine.

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

This paper develops a 3D tumor sphere culture-transplant system to study human breast cancer metastasis using patient-derived xenografts and validates its utility for functional metastasis assays.

Disrupting β-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progression

This study shows that reducing Wnt signaling in colon cancer cells increases their invasiveness and identifies gene markers predictive of poor patient outcomes.

Analysis of Spounaviruses as a Case Study for the Overdue Reclassification of Tailed Bacteriophages

The paper evaluates taxonomy methods for bacteriophages using Spounavirinae as a case study, finding they should be divided into at least five subfamilies.