Low-dose cytokine immunotherapy of solid cancers enabled by phagocytic-competent protein co-crystals
M. H. Jones, N. E. Quispe Calla, R. Smith, C. Talbot Cooper, S. Rudge, H. Kusano, T. Shiomi, Y. Ishikawa, H. Zeng, J. D. Best
This study demonstrates that PODS-IL-2, a phagocytic-competent protein co-crystal, can deliver low-dose IL-2 effectively for treating melanoma and renal cell carcinoma with improved tolerability.
bioRxiv · Apr 6, 2023 · PreprintCancer Biology