Mechanism of broad-spectrum Cas9 inhibition by AcrIIA11
K. E. Dillard, C. Terrace, K. Javanmardi, W. Kim, K. J. Forsberg, I. J. Finkelstein
This study shows AcrIIA11 inhibits multiple Cas9 variants by trapping them on non-specific DNA, preventing target recognition and cleavage.
bioRxiv · Sep 15, 2021 · PreprintBiophysics