Author

K. J. Forsberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

B. K. Kaiser· 2 shared B. L. Stoddard· 2 shared D. T. Schmidtke· 2 shared H. S. Malik· 2 shared B. L. Bassler· 1 shared C. Terrace· 1 shared D. Hausman· 1 shared F. A. Hussain· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

B. K. Kaiser

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Small protein modules dictate prophage fates during polylysogeny

J. E. Silpe, O. P. Duddy, F. A. Hussain, K. J. Forsberg, B. L. Bassler

The paper identifies small protein modules in phages that independently control prophage induction without relying on DNA damage cues, revealing alternative pathways for lysis in polylysogeny.

bioRxiv · Sep 16, 2022Microbiology

Mechanism of broad-spectrum Cas9 inhibition by AcrIIA11

K. E. Dillard, C. Terrace, K. Javanmardi, W. Kim, K. J. Forsberg, I. J. Finkelstein

This study shows AcrIIA11 inhibits multiple Cas9 variants by trapping them on non-specific DNA, preventing target recognition and cleavage.

bioRxiv · Sep 15, 2021 · PreprintBiophysics

The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity

K. J. Forsberg, D. T. Schmidtke, R. Werther, R. V. Uribe, D. Hausman, M. O. A. Sommer, B. L. Stoddard, B. K. Kaiser, H. S. Malik

The paper identifies AcrIIA22 as an anti-CRISPR protein that inhibits SpyCas9 by relieving DNA torsion in plasmids.

bioRxiv · Sep 28, 2020 · PreprintMicrobiology

Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

K. J. Forsberg, I. V. Bhatt, D. T. Schmidtke, B. L. Stoddard, B. K. Kaiser, H. S. Malik

The paper identifies potent Cas9 inhibitors from human microbiomes using functional metagenomics, discovering AcrIIA11 as a strong inhibitor with a novel mechanism.

bioRxiv · Mar 6, 2019Microbiology