Author

K. Javanmardi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

I. J. Finkelstein· 5 shared C.-W. Chou· 3 shared A. Annapareddy· 2 shared D. R. Boutz· 2 shared H.-C. Kuo· 2 shared J. D. Gollihar· 2 shared A. D. Ellington· 1 shared A. Dzifa· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersBiochemistry

I. J. Finkelstein

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Antibody escape and cryptic cross-domain stabilization in the SARS CoV-2 Omicron spike protein

K. Javanmardi, T. H. Segall-Shapiro, C.-W. Chou, D. R. Boutz, R. J. Olsen, X. Xie, H. Xia, P.-Y. Shi, C. D. Johnson, A. Annapareddy, S. Weaver, J. M. Musser, A. D. Ellington, I. J. Finkelstein, J. D. Gollihar

This study examines the molecular effects of Omicron spike mutations on ACE2 binding and antibody escape, revealing compensatory stabilizing mutations that enable high mutation counts.

bioRxiv · Apr 18, 2022Immunology

Mechanism of broad-spectrum Cas9 inhibition by AcrIIA11

K. E. Dillard, C. Terrace, K. Javanmardi, W. Kim, K. J. Forsberg, I. J. Finkelstein

This study shows AcrIIA11 inhibits multiple Cas9 variants by trapping them on non-specific DNA, preventing target recognition and cleavage.

bioRxiv · Sep 15, 2021 · PreprintBiophysics

Rapid characterization of spike variants via mammalian cell surface display

K. Javanmardi, C.-W. Chou, C. I. Terrace, A. Annapareddy, T. S. Kaoud, Q. Guo, J. Lutgens, H. Zorkic, A. P. Horton, E. C. Gardner, G. Nguyen, D. R. Boutz, J. Goike, W. N. Voss, H.-C. Kuo, , I. J. Finkelstein

This study characterizes SARS-CoV-2 spike variants by assessing their expression, ACE2 binding, and neutralizing antibody recognition across multiple variants.

bioRxiv · Mar 30, 2021Biochemistry

Disintegration promotes proto-spacer integration by the Cas1-Cas2 complex

C.-H. Ma, K. Javanmardi, I. J. Finkelstein, M. Jayaram

The paper investigates the role of disintegration in proto-spacer integration by the Cas1-Cas2 complex, showing it facilitates integration through DNA repair pathways.

bioRxiv · Dec 21, 2020Biochemistry

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes

C.-L. Hsieh, J. A. Goldsmith, J. M. Schaub, A. M. DiVenere, H.-C. Kuo, K. Javanmardi, K. C. Le, D. Wrapp, A. G.-W. Lee, Y. Liu, C.-W. Chou, P. O. Byrne, C. K. Hjorth, N. V. Johnson, J. Ludes-Meyers, , J. S. McLellan

This study designs and characterizes prefusion-stabilized SARS-CoV-2 spike variants to improve protein yield and stability for vaccine and diagnostic development.

bioRxiv · May 30, 2020Microbiology