Author

C. Thorlaksen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

N. S. Hatzakis· 3 shared M. Groenning· 2 shared V. Fodera· 2 shared A.-M. Stanciu· 1 shared C. Bartholdy· 1 shared F. S. Nielsen· 1 shared H. S. Schultz· 1 shared H. Solberg· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

N. S. Hatzakis

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Author profile →

3 papers

Recent·Most cited

In vitro and in vivo immunogenicity assessment of protein aggregate characteristics

C. Thorlaksen, H. S. Schultz, S. K. Gammelgaard, W. Jiskoot, N. S. Hatzakis, F. S. Nielsen, H. Solberg, V. Fodera, C. Bartholdy, M. Groenning

This study assesses the immunogenicity of human insulin aggregates with varying size, structure, and modifications, finding that flexible aggregates with altered secondary structure are most immunogenic.

bioRxiv · Jul 6, 2022Immunology

Morphological integrity of insulin amyloid-like aggregates depends on preparation methods and post-production treatments

C. Thorlaksen, A.-M. Stanciu, M. B. Neergaard, N. S. Hatzakis, V. Fodera, M. Groenning

This study investigates how preparation methods and post-treatment affect the morphology and integrity of insulin amyloid-like aggregates.

bioRxiv · Jun 27, 2022Biophysics

Label free fluorescence quantification of hydrolytic enzyme activity on native substrates reveal how lipase function depends on membrane curvature

S. S.- R. Bohr, C. Thorlaksen, R. M. Kuhnel, T. Gunther-Pomorski, N. S. Hatzakis

This paper introduces a fluorescent assay to measure lipase activity on native substrates by detecting changes in membrane environment, revealing how membrane curvature and lid region mutations affect lipase function.

bioRxiv · Mar 18, 2020Biochemistry