Allosteric Competition and Inhibition in AMPA Receptors
W. D. Hale, A. M. Romero, C. U. Gonzalez, V. Jayaraman, A. Y. Lau, R. L. Huganir, E. C. Twomey
This study reveals how negative allosteric modulators inhibit AMPA receptors by disrupting glutamate binding and outcompeting positive modulators, offering insights for therapeutic design.
bioRxiv · Nov 28, 2023Biophysics