Author

E. C. Twomey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. M. Romero· 2 shared R. L. Huganir· 2 shared W. D. Hale· 2 shared A. Montano Romero· 1 shared A. Y. Lau· 1 shared C. Bonin· 1 shared C. U. Gonzalez· 1 shared V. Jayaraman· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

A. M. Romero

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3 papers

Recent·Most cited

Structure of Transmembrane AMPA Receptor Regulatory Protein Subunit γ2

W. D. Hale, A. M. Romero, R. L. Huganir, E. C. Twomey

The paper determines the structure of the TARP subunit γ2 using cryo-EM and identifies structural motifs that differentiate TARPs from claudins and explain subfamily variations.

Nature Communications · Jan 15, 2025Peer-reviewedBiophysics

Allosteric Competition and Inhibition in AMPA Receptors

W. D. Hale, A. M. Romero, C. U. Gonzalez, V. Jayaraman, A. Y. Lau, R. L. Huganir, E. C. Twomey

This study reveals how negative allosteric modulators inhibit AMPA receptors by disrupting glutamate binding and outcompeting positive modulators, offering insights for therapeutic design.

bioRxiv · Nov 28, 2023Biophysics

Time-Resolved Cryo-EM Specimen Preparation with Single Millisecond Precision

A. Montano Romero, C. Bonin, E. C. Twomey

This paper introduces C-SPAM, a device for time-resolved cryo-EM with single millisecond precision, enabling capture of short-lived molecular states.

bioRxiv · Aug 24, 2023Biophysics