Author

A. Y. Lau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 5 Approach:deep learning· 4 Approach:experimental assay· 2 Approach:mechanistic / dynamical model· 2 Approach:statistical model· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

R. A. Yovanno· 4 shared A. F. Bandak· 1 shared A. M. Romero· 1 shared A. Yu· 1 shared B. M. Britton· 1 shared C. U. Gonzalez· 1 shared D. J. Evans· 1 shared D. W. Cao· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersBiophysics

R. A. Yovanno

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Allosteric Competition and Inhibition in AMPA Receptors

W. D. Hale, A. M. Romero, C. U. Gonzalez, V. Jayaraman, A. Y. Lau, R. L. Huganir, E. C. Twomey

This study reveals how negative allosteric modulators inhibit AMPA receptors by disrupting glutamate binding and outcompeting positive modulators, offering insights for therapeutic design.

bioRxiv · Nov 28, 2023Biophysics

Conformational changes in the essential E. coli septal cell wall synthesis complex suggest an activation mechanism

B. M. Britton, R. A. Yovanno, S. F. Costa, J. McCausland, A. Y. Lau, J. Xiao, Z. Hensel

This study models the E. coli divisome core complex using structure prediction and simulations, revealing how FtsN activates cell wall synthesis by tethering FtsI and FtsL.

bioRxiv · Nov 27, 2022 · PreprintBiophysics

NIS metastable intermediates provide insights into conformational transition between principal thermodynamic states

M. Chakrabarti, L. M. Amzel, A. Y. Lau

This study uses enhanced sampling and MD simulations to identify intermediate states of NIS during conformational transitions between inwardly and outwardly open states.

bioRxiv · Oct 13, 2022 · PreprintBiophysics

Phosphorylation at Ser65 modulates ubiquitin conformational dynamics

R. A. Yovanno, A. Yu, T. J. Wied, A. Y. Lau

This study investigates how phosphorylation at Ser65 affects ubiquitin's conformational dynamics by identifying a stable intermediate state and its role in conformational transitions.

bioRxiv · Aug 9, 2022Biophysics

Excitatory and inhibitory D-serine binding to the NMDA receptor

R. A. Yovanno, T. H. Chou, S. J. Brantley, H. Furukawa, A. Y. Lau

This study investigates D-serine binding to NMDA receptor subunits using simulations and electrophysiology, revealing competitive binding with glutamate and inhibitory effects at high concentrations.

bioRxiv · Mar 7, 2022Biophysics

Finding Druggable Sites in Proteins using TACTICS

D. J. Evans, R. A. Yovanno, S. Rahman, D. W. Cao, M. Q. Beckett, M. H. Patel, A. F. Bandak, A. Y. Lau

TACTICS identifies druggable sites in proteins using molecular dynamics data, clustering, random forest, and fragment docking, predicting novel binding sites in SARS-CoV-2 and Yersinia pestis proteins.

bioRxiv · Feb 21, 2021Biophysics