Connective-Tissue Growth Factor (CTGF/CCN2) Contributes to TGF-β1-Induced Lung Fibrosis
T. Yanagihara, S. G. Chong, M. Gholiof, K. E. Lipson, Q. Zhou, C. Scallan, C. Upagupta, J. Tikkanen, S. Keshavjee, K. Ask, M. R. Kolb
This study shows CTGF contributes to TGF-β1-induced lung fibrosis in a rat model and patients with IPF, and that pamrevlumab can partially reduce fibrosis.
bioRxiv · Jul 4, 2020 · PreprintCell Biology