S. Keshavjee

Emergence of a senescent and inflammatory pulmonary CD4+ T cell population prior to lung allograft failure

The paper identifies CD4+CD57+PD1+ T cells in lung transplant recipients that predict allograft dysfunction and are associated with fibrosis in both human and mouse models.

Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation

The paper identifies two macrophage subsets in lung transplant recipients associated with acute and chronic allograft dysfunction using single-cell RNA sequencing.

Pro-inflammatory alveolar macrophages associated with allograft dysfunction after lung transplantation

The paper uses scRNA-seq to analyze BAL cells from lung transplant patients, identifying pro-inflammatory macrophage subsets linked to allograft dysfunction.

Ex vivo delivery of regulatory T cells for control of alloimmune priming in the donor lung

This study shows that ex vivo delivery of regulatory T cells to donor lungs before transplantation can suppress alloimmune responses and improve lung graft outcomes in a rat model.

Connective-Tissue Growth Factor (CTGF/CCN2) Contributes to TGF-β1-Induced Lung Fibrosis

This study shows CTGF contributes to TGF-β1-induced lung fibrosis in a rat model and patients with IPF, and that pamrevlumab can partially reduce fibrosis.