Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia
C. Vandersmissen, S. Demeyer, K. Jacobs, L. Boogaerts, S. G. Fernandez, H. Segers, L. Chavez-Gutierrez, J. Cools
The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.
bioRxiv · Mar 1, 2024 · PreprintCancer Biology