Author

L. Boogaerts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

H. Segers· 2 shared J. Cools· 2 shared K. Jacobs· 2 shared S. Demeyer· 2 shared A. Veloso· 1 shared C. Vandersmissen· 1 shared D. Dierickx· 1 shared F. Renard· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

H. Segers

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Dual targeting of EZH2 and Histone Deacetylases in hematological malignancies promotes transcriptional and metabolic deregulation leading to ferroptosis

A. Veloso, T. Slegers, J. Schoenaker, S. Demeyer, S. Van den Bergh, M. Aertgeerts, K. Verhoeft, Y. Schoenmaekers, N. Meeuws, I. Bischops, F. Renard, L. Boogaerts, N. Mentens, O. Gielen, K. Jacobs, , M. Vanden Bempt

This study shows that targeting EZH2 and HDACs together induces ferroptosis in hematological malignancies by upregulating cholesterol biosynthesis and causing metabolic stress.

bioRxiv · Mar 3, 2024 · PreprintCancer Biology

Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

C. Vandersmissen, S. Demeyer, K. Jacobs, L. Boogaerts, S. G. Fernandez, H. Segers, L. Chavez-Gutierrez, J. Cools

The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.

bioRxiv · Mar 1, 2024 · PreprintCancer Biology