Author

L. Chavez-Gutierrez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Hopf· 2 shared S. Lismont· 2 shared T. Enzlein· 2 shared A. Becker· 1 shared B. Ozcan· 1 shared C. Vandersmissen· 1 shared D. Gomes Moreira· 1 shared D. Karachentsev· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. Hopf

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

C. Vandersmissen, S. Demeyer, K. Jacobs, L. Boogaerts, S. G. Fernandez, H. Segers, L. Chavez-Gutierrez, J. Cools

The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.

bioRxiv · Mar 1, 2024 · PreprintCancer Biology

APP substrate ectodomain defines A beta length by restraining gamma-secretase processivity and facilitating product release

M. Koch, T. Enzlein, S.-Y. Chen, D. Petit, S. Lismont, M. Zacharias, C. Hopf, L. Chavez-Gutierrez

The paper investigates how the APP ectodomain regulates gamma-secretase processivity and A beta peptide length, identifying it as a target for Alzheimer's disease therapies.

bioRxiv · Sep 13, 2023 · PreprintBiochemistry

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

K. M. Zoltowska, U. Das, S. Lismont, T. Enzlein, M. Maesako, M. C. Houser, D. Gomes Moreira, M. L. Franco, B. Ozcan, D. Karachentsev, A. Becker, C. Hopf, M. Vilar, O. Berezovska, W. Mobley, L. Chavez-Gutierrez

This study shows that human Aβ42 inhibits γ-secretase, leading to substrate accumulation and neuronal dysfunction, suggesting a feedback mechanism in Alzheimer's disease.

bioRxiv · Aug 2, 2023Biochemistry