Structure and computation-guided design of a mutation-integrated trimeric RBD candidate vaccine with broad neutralization against SARS-CoV-2
Y. Liang, J. Zhang, R. Y. Yuan, M. Y. Wang, P. He, J. G. Su, Z. B. Han, Y. Q. Jin, J. W. Hou, H. Zhang, X. F. Zhang, S. Shao, Y. N. Hou, Z. M. Liu, L. F. Du, , Q. M. Li
This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.
bioRxiv · Jun 18, 2021 · PreprintImmunology