S. Shao

The Effect of Adrenalectomy on Bleomycin-Induced Pulmonary Fibrosis in Mice

This study investigates the effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice, finding that adrenalectomy reduces lung remodeling but not collagen deposition.

A General-Purpose Non-invasive Neurotechnology Research Platform

The paper introduces a non-invasive neurotechnology platform with multi-modal sensors and integration into BCI2000, demonstrating its use in sleep monitoring and evoked potentials.

Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7

This study identifies Hmg20a and Nol9 as host factors restricting L. pneumophila replication by repressing Rab7, which is co-opted by the bacterium via SulF to facilitate phagosome biogenesis.

Convergent mutations in phage virion assembly proteins enable evasion of Type I CBASS immunity

The paper identifies mutations in phage virion assembly proteins that enable evasion of Type I CBASS immunity by altering infection kinetics.

Giants among Cnidaria: large nuclear genomes and rearranged mitochondrial genomes in siphonophores

This study uses Illumina sequencing to analyze genome diversity in siphonophores, revealing large nuclear genomes and rearranged mitochondrial genomes, identifying optimal species for future genomic work.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

A pilot study of stable isotope fractionation in Bombyx mori rearing

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

Didemnin B and ternatin-4 inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes

This study shows how didemnin B and ternatin-4 inhibit translation by trapping eEF1A in a GTPase-activated conformation using single-molecule imaging and cryo-EM.

A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

This study develops a mosaic-type trimeric RBD vaccine that induces strong neutralizing antibodies against Omicron and other SARS-CoV-2 variants in rats.

Structure and computation-guided design of a mutation-integrated trimeric RBD candidate vaccine with broad neutralization against SARS-CoV-2

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.

In the absence of reproductive isolation - Extensive gene flow after speciation

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

FLS2 is a CDK-like kinase that directly binds IFT70 and is required for proper ciliary disassembly in Chlamydomonas

LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force

This study shows LIMD1 phase separation at focal adhesions regulates force sensing and durotaxis by controlling FA dynamics in response to mechanical cues.

Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology

The paper introduces an improved scRNA-Seq protocol, Seq-Well S^3, which enhances transcript capture and gene detection efficiency, and applies it to study inflammatory skin diseases.

Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering

The paper shows nuclear actin enhances RNA polymerase II clustering during inducible transcription, facilitating rapid gene expression in response to stimuli like serum and interferon-gamma.

MapZ forms a stable ring structure that acts as a nano-track for FtsZ treadmilling in Streptococcus mutans

This study shows MapZ forms a stable ring in Streptococcus mutans that guides FtsZ treadmilling, controlling cell division.