F. Zheng

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

This study shows miR-574-5p activates TLR8 to drive autoimmune signaling and lupus progression by enhancing cytokine production, STAT1 activation, and autoantigen generation.

A KDELR-mediated ER retrieval system guides the signaling pathways of UPR and AMPK to maintain cellular homeostasis

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology

This paper reports high-resolution structures of Rad24-RFC loading 9-1-1 onto DNA gaps, showing preference for ssDNA gaps and revealing a unique mechanism for clamp loading and DNA repair.

Disulfiram Exerts anti-pulmonary Fibrosis Effect by Activating PGE2 Synthesis

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

BCM PDX Portal: An Intuitive Web-based Tool for Patient-Derived Xenograft Collection Management, as well as Visual Integration of Clinical and Omics Data

The BCM PDX Portal manages PDX collections and integrates clinical and omics data for drug evaluation.

Genetically encoded photocatalytic protein labeling enables spatially-resolved profiling of intracellular proteome

The paper introduces a method to label and profile subcellular proteins in living cells using a genetically encoded photocatalyst and reactive probes, achieving high specificity in mitochondrial proteome analysis.

Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

This study improves sgRNA activity predictions by incorporating tracrRNA sequence variations, showing better performance than existing models on a new dataset.

The production of diverse brGDGTs by an Acidobacterium allows a direct test of temperature and pH controls on their distribution

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair

Rad24-RFC loads the 9-1-1 clamp by inserting DNA from the top of a wide-open ring, opposite the mechanism of RFC/PCNA

This paper reveals the mechanism by which Rad24-RFC loads the 9-1-1 clamp onto DNA by inserting ssDNA from the top of an open ring, differing from RFC/PCNA loading.

Structure and computation-guided design of a mutation-integrated trimeric RBD candidate vaccine with broad neutralization against SARS-CoV-2

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.

The intestinal microbiota-driven dopamine level influences social interaction and innate color preference in zebrafish larvae

This study shows that gut microbiota influence dopamine levels, which in turn affect social interaction and color preference in zebrafish larvae.

Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

Tissue and regional expression patterns of dicistronic tRNA-mRNA transcripts in grapevine (Vitis vinifera) and their evolutionary co-appearance with vasculature in land plants

The paper identifies dicistronic tRNA-mRNA transcripts in grapevine and shows their tissue-specific expression and evolutionary link to vascular land plants.

Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I

This study compares spindle dynamics in mitosis and meiosis I using fission yeast, showing Klp2 maintains meiotic spindle stability with Ase1, but not mitotic spindles.

Clinical Significance of C4d Deposition in Renal Tissues from Patients with Primary Sj&oumlgren's Syndrome--A Preliminary Study

This study examines C4d deposition in renal tissues of primary Sjögren's syndrome patients, finding higher serum creatinine levels in those with tubulointerstitial C4d positivity.

Characterizing Activity and Thermostability of GH5 Cellulase Chimeras from Mesophilic and Thermophilic Parents

This study creates GH5 cellulase hybrids from mesophilic and thermophilic parents to identify elements enhancing thermostability, finding improved thermal properties in some hybrids.