Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2
R. Ferreira de Freitas, Y. Liu, M. Szewczyk, N. Mehta, F. Li, D. McLeod, C. Zepeda-Velazquez, D. Dilworth, R. P. Hanley, E. Gibson, P. J. Brown, R. Al-Awar, L. Ingerman James, C. H. Arrowsmith, D. Barsyte-Lovejoy, , A. Allali-Hassani
This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.
bioRxiv · Nov 25, 2020Pharmacology & Toxicology