Author

R. Al-Awar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 4 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:protein structure· 1

Frequent Co-Authors

C. H. Arrowsmith· 4 shared M. Schapira· 4 shared M. Vedadi· 4 shared P. J. Brown· 4 shared C. A. Zepeda-Velazquez· 3 shared D. Barsyte-Lovejoy· 3 shared D. McLeod· 3 shared F. Li· 3 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersBiochemistry

C. H. Arrowsmith

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Author profile →

5 papers

Recent·Most cited

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

S. Perveen, C. A. Zepeda-Velazquez, D. McLeod, R. Marcellus, M. Mohammed, M. Abbey, D. Ensan, D. Panagopoulos, V. Trush, E. Gibson, A. Dong, L. Halabelian, G. Poda, J. Owen, A. Aman, , M. Vedadi

This study identifies small molecule antagonists of RBBP4's top pocket, competes with protein and histone interactions, and reports the first crystal structure of RBBP4 with a small molecule.

bioRxiv · Jan 5, 2022 · PreprintBiochemistry

Structure Activity Relationship of USP5 Allosteric Inhibitors

M. K. Mann, C. A. Zepeda-Velazquez, H. G. Alvarez, A. Dong, T. Kiyota, A. Aman, C. Arrowsmith, R. Al-Awar, R. J. Harding, M. Schapira

This paper develops a chemical series of USP5 allosteric inhibitors, identifies a selective compound with structural and functional characterization.

bioRxiv · May 17, 2021 · PreprintBiochemistry

A First-in-class, Highly Selective and Cell-active AllostericInhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

Y. Shen, F. Li, M. Szewczyk, L. Halabelian, I. Chau, M. S. Eram, C. Dela Sena, K.-S. Park, F. Meng, H. Chen, H. Zeng, D. McLeod, C. A. Zepeda-Velazquez, R. M. Campbell, M. M. Mader, , J. Jin

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

bioRxiv · Dec 4, 2020 · PreprintBiochemistry

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

R. Ferreira de Freitas, Y. Liu, M. Szewczyk, N. Mehta, F. Li, D. McLeod, C. Zepeda-Velazquez, D. Dilworth, R. P. Hanley, E. Gibson, P. J. Brown, R. Al-Awar, L. Ingerman James, C. H. Arrowsmith, D. Barsyte-Lovejoy, , A. Allali-Hassani

This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.

bioRxiv · Nov 25, 2020Pharmacology & Toxicology

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

M. M. Szewczyk, Y. Ishikawa, S. Organ, N. Sakai, F. Li, S. Ackloo, M. S. Eram, D. Dilworth, H. Fukushi, R. Harding, C. C. dela Sena, T. Sugo, K. Hayashi, D. Macleod, C. Zepeda, , D. Barsyte-Lovejoy

This study identifies a PRMT7 inhibitor and shows its effect on arginine methylation of stress proteins, linking PRMT7 to cellular stress response.

bioRxiv · Mar 15, 2019Biochemistry