Author

A. Allali-Hassani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Min· 3 shared M. Schapira· 3 shared M. Vedadi· 3 shared R. Ferreira de Freitas· 3 shared A. Dong· 2 shared C. H. Arrowsmith· 2 shared D. Barsyte-Lovejoy· 2 shared D. Dilworth· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

J. Min

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Author profile →

3 papers

Recent·Most cited

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

D. Dilworth, R. P. Hanley, R. Ferreira de Freitas, A. Allali-Hassani, M. Zhou, N. Mehta, M. R. Marunde, S. Ackloo, E. Marcon, F. Li, I. Chau, A. Bolotokova, S. Qin, M. Lei, Y. Liu, , M. Schapira

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

bioRxiv · Mar 5, 2021 · PreprintCell Biology

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

R. Ferreira de Freitas, Y. Liu, M. Szewczyk, N. Mehta, F. Li, D. McLeod, C. Zepeda-Velazquez, D. Dilworth, R. P. Hanley, E. Gibson, P. J. Brown, R. Al-Awar, L. Ingerman James, C. H. Arrowsmith, D. Barsyte-Lovejoy, , A. Allali-Hassani

This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.

bioRxiv · Nov 25, 2020Pharmacology & Toxicology

Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain

P. Mader, R. Mendoza-Sanchez, A. Iqbal, A. Dong, E. Dobrovetsky, V. Corless, S. Liew, S. Houliston, R. Ferreira De Freitas, D. Smil, C. Dela Sena, S. Kennedy, D. Diaz, H. Wu, L. Dombrovski, , C. Arrowsmith

The paper identifies small molecule fragments that bind to the tudor domain of SETDB1 and describes their binding modes and biophysical properties.

Bioorganic & Medicinal Chemistry · Sep 1, 2019Peer-reviewedPharmacology & Toxicology