Author

R. P. Hanley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Barsyte-Lovejoy· 3 shared F. Li· 3 shared M. Szewczyk· 3 shared A. Allali-Hassani· 2 shared C. H. Arrowsmith· 2 shared D. Dilworth· 2 shared E. Gibson· 2 shared J. Min· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

D. Barsyte-Lovejoy

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Author profile →

3 papers

Recent·Most cited

Recruitment of FBXO22 for Targeted Degradation of NSD2

D. Y. Nie, J. R. Tabor, J. Li, M. Kutera, J. St-Germain, R. P. Hanley, E. Z. WOLF, E. Paulakonis, T. M. G. Kenney, S. Duan, S. Shrestha, D. D. Owens, A. Pon, M. Szewczyk, A. J. Lamberto, , C. Arrowsmith

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

bioRxiv · Nov 1, 2023Biochemistry

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

D. Dilworth, R. P. Hanley, R. Ferreira de Freitas, A. Allali-Hassani, M. Zhou, N. Mehta, M. R. Marunde, S. Ackloo, E. Marcon, F. Li, I. Chau, A. Bolotokova, S. Qin, M. Lei, Y. Liu, , M. Schapira

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

bioRxiv · Mar 5, 2021 · PreprintCell Biology

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

R. Ferreira de Freitas, Y. Liu, M. Szewczyk, N. Mehta, F. Li, D. McLeod, C. Zepeda-Velazquez, D. Dilworth, R. P. Hanley, E. Gibson, P. J. Brown, R. Al-Awar, L. Ingerman James, C. H. Arrowsmith, D. Barsyte-Lovejoy, , A. Allali-Hassani

This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.

bioRxiv · Nov 25, 2020Pharmacology & Toxicology