Complement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.
A. J. Wood, A. M. Vassallo, M.-H. Ruchard-Sparagano, J. Scott, C. Zinnato, C. Gonzalez-Tejedo, K. Kishore, C. D'Santos, A. J. Simpson, D. Menon, C. Summers, E. R. Chilvers, K. Okkenhaug, A. Conway Morris
This study identifies C5a-induced phosphoproteomic changes in human neutrophils that impair phagosomal maturation and acidification, leading to reduced killing of Staphylococcus aureus.
bioRxiv · Jan 17, 2020Immunology