Author

K. Okkenhaug

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. Chandra· 2 shared D. J. Adams· 2 shared J. R. Edgar· 2 shared A. A. Peden· 1 shared A. Conway Morris· 1 shared A. Cope· 1 shared A. Firth· 1 shared A. G. Richter· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersImmunology

A. Chandra

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

An evolutionary-conserved VPS34-PIKfyve-TRPML1-Myosin II axis regulates the speed of amoeboid cell migration

P. Dehio, C. Michard, J. C. Yam-Puc, A.-A. Marti i Lindez, L. Fabre, T. Schaefer, M. P. Wymann, K. Okkenhaug, T. Soldati, M. Mehling, C. Hess

This study identifies a conserved VPS34-PIKfyve-TRPML1-Myosin II axis that controls the speed of amoeboid cell migration by regulating retrograde actin flow through Ca2+ efflux.

bioRxiv · Jan 22, 2024Cell Biology

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

C. J. Courreges, E. C. Davenport, B. Bilanges, E. Rebollo-Gomez, J. Hukelmann, P. Schoenfelder, J. R. Edgar, D. Sansom, C. Scudamore, R. Roychoudhuri, O. A. Garden, B. Vanhaesebroeck, K. Okkenhaug

This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.

bioRxiv · Jan 8, 2024Immunology

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

M. Takahashi, T. So, K. Williamson, Z. Hosseini, K. Kania, M. Ruhle, T. Mann, M. J. Schujis, P. Coupland, D. Naisbitt, T. Y. F. Halim, P. A. Lyons, P. Lio, K. Okkenhaug, D. J. Adams, , J. E. D. Thaventhiran

This study introduces a novel fate-mapping mouse to track lymphocyte clones and their progenies in response to antigen signals, revealing distinct T cell behaviors in tumor immunity.

bioRxiv · Mar 16, 2023Immunology

Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

H. Stewart, R. Palmulli, K. H. Johansen, N. McGovern, O. M. Shehata, G. W. Carnell, H. K. Jackson, J. S. Lee, J. C. Brown, T. C. Burgoyne, J. L. Heeney, K. Okkenhaug, A. Firth, A. A. Peden, J. R. Edgar

This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.

bioRxiv · Jan 6, 2021Cell Biology

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

B. Mahata, J. Pramanik, L. v. d. Weyden, K. Polanski, G. Kar, A. Riedel, X. Chen, N. A. Fonseca, K. Kundu, L. S. Campos, E. Ryder, G. Duddy, I. Walczak, K. Okkenhaug, D. J. Adams, , S. A. Teichmann

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

bioRxiv · Jun 14, 2020Immunology

Complement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.

A. J. Wood, A. M. Vassallo, M.-H. Ruchard-Sparagano, J. Scott, C. Zinnato, C. Gonzalez-Tejedo, K. Kishore, C. D'Santos, A. J. Simpson, D. Menon, C. Summers, E. R. Chilvers, K. Okkenhaug, A. Conway Morris

This study identifies C5a-induced phosphoproteomic changes in human neutrophils that impair phagosomal maturation and acidification, leading to reduced killing of Staphylococcus aureus.

bioRxiv · Jan 17, 2020Immunology

Cholesterol metabolism drives regulatory B cell function

J. A. Bibby, H. A. Purvis, T. Hayday, A. Chandra, K. Okkenhaug, M. Wood, H. J. Lachmann, C. Kemper, A. Cope, E. Perucha

This study shows that cholesterol metabolism, specifically through GGPP synthesis, is essential for regulatory B cell function by promoting IL-10 production and suppressing Th1 responses.

bioRxiv · Jan 3, 2020Immunology

PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

A.-K. Stark, A. Chandra, K. Chakraborty, R. Alam, V. Carbonaro, J. Clark, S. Sriskantharajah, G. Bradley, A. G. Richter, E. Banham-Hall, M. R. Clatworthy, S. Nejentsev, J. N. Hamblin, E. M. Hessel, A. M. Condliffe, K. Okkenhaug

This study identifies a PI3Kδ-driven B cell subset in the lungs that worsens Streptococcus pneumoniae infection independently of antibodies, and shows that inhibiting PI3Kδ improves survival.

bioRxiv · Mar 18, 2018Immunology