Phenolic glycolipid facilitates mycobacterial escape from a microbicidal population of tissue-resident macrophages
C.J. Cambier, Seónadh M. O’Leary, Mary P. O’Sullivan, Joseph Keane, Lalita Ramakrishnan
The paper shows that mycobacteria use phenolic glycolipid (PGL) to escape resident macrophages by activating the STING pathway and recruiting monocytes, suggesting PGL-blocking interventions could prevent tuberculosis.
bioRxiv · Jun 7, 2017 · PreprintImmunology