Author

Seónadh M. O’Leary

Trinity College DublinORCID 0000-0002-7903-2325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:imaging· 1 Organism:zebrafish· 1

Frequent Co-Authors

Joseph KeaneiD· 2 shared Mary P. O’SullivaniD· 2 shared Aaron M. WalshiD· 1 shared Anjali S YennemadiiD· 1 shared C.J. Cambier· 1 shared Dearbhla M MurphyiD· 1 shared Gina R. LeischingiD· 1 shared Grainne Jameson· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Joseph KeaneORCID

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2 papers

Recent·Most cited

ImmunologyScientific ReportsPeer-reviewedMay 7, 2026

HIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis.

Kevin Edward Brown, Aaron M. Walsh, Anjali S Yennemadi…·Joseph Keane

This study shows HIV-1 infection suppresses Mtb-induced glycolytic reprogramming in macrophages, altering immunometabolic responses and increasing TB susceptibility.

2 citationstop 4%

humanbulk RNA-seq

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ImmunologybioRxivPreprintJun 7, 2017

Phenolic glycolipid facilitates mycobacterial escape from a microbicidal population of tissue-resident macrophages

C.J. Cambier, Seónadh M. O’Leary, Mary P. O’Sullivan…·Lalita Ramakrishnan

The paper shows that mycobacteria use phenolic glycolipid (PGL) to escape resident macrophages by activating the STING pathway and recruiting monocytes, suggesting PGL-blocking interventions could prevent tuberculosis.

DOI 10.1101/147421

zebrafishhuman

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