Embryonic lympho-epithelial cell interactions play an essential role in the establishment of adult T cell tolerance
Gonçalo Nogueira, Almira A. Chervova, Francisca Soares‐da‐Silva, Arnauld Sergé, Magali Irla, Cabe C. Moraes, Aurore Gaudin, Pedro Ferreirinha, António Bandeira, Nuno L. Alves, Pablo Pereira, Ana Cumano
This study shows that early thymic seeding progenitors are crucial for thymic epithelial maturation and regulatory T cell development, preventing age-related autoimmunity.
bioRxiv · Jan 19, 2026 · PreprintImmunology