Ana Cumano

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

This study shows that early thymic seeding progenitors are crucial for thymic epithelial maturation and regulatory T cell development, preventing age-related autoimmunity.

The paper identifies distinct roles for embryonic multipotent progenitors (eMPP) and hematopoietic stem cells (HSC) in fetal hematopoiesis and immune system development.

The paper identifies hemogenic endothelium in vitelline and umbilical arteries as a major source of fetal lympho-myeloid progenitors in mice, showing their transient contribution before definitive HSCs emerge.

The paper identifies the spatiotemporal dynamics of cytokine expression in fetal liver hematopoiesis, showing that hepatoblasts and mesothelial cells produce key growth factors and cytokines.

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

The paper identifies fetal liver stromal subsets using spectral cytometry and autofluorescence, finding two distinct autofluorescent signals corresponding to hepatoblasts/cholangiocytes and stellate cells.

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.

This study shows yolk sac erythromyeloid progenitors sustain erythropoiesis throughout embryonic life by outcompeting hematopoietic stem cell-derived progenitors in low erythropoietin environments.

The paper identifies HSA/CD24+ immature cardiomyocytes that persist in adult hearts and expand after ischemic injury.

This study identifies Rvfs2 as a genetic locus that restricts RVFV replication and enables survival from acute liver disease in mice.