Activation of MAP3K DLK and LZK in Purkinje Cells Causes Rapid and Slow Degeneration Depending on Signaling Strength
Yunbo Li, Erin M Ritchie, Christopher L Steinke, Cai Qi, Lizhen Chen, Binhai Zheng, Yishi Jin
This study shows that activating DLK or LZK in Purkinje cells leads to rapid or slow degeneration, respectively, with LZK's effect modulated by CELF2 and Mkk7 splicing.
eLife · Jan 21, 2021Peer-reviewedNeuroscience