Lizhen Chen

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

This study shows CELF2 regulates Tau exon 10 inclusion via IDR-mediated nuclear condensation with NOVA2 and SFPQ, affecting the 4R:3R ratio in mice.

This study shows that optimal AR NTD multivalent interactions are required for enhancer assembly and transcriptional activity, with excessive condensation impairing function and potentially contributing to disease.

This study shows that activating DLK or LZK in Purkinje cells leads to rapid or slow degeneration, respectively, with LZK's effect modulated by CELF2 and Mkk7 splicing.