APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ
Mengxun Luo, Jia Zhou, Cailu Sun, Wanjia Chen, Chaoying Fu, Chenfang Si, Yaoyang Zhang, Yang Geng, Yelin Chen
This study shows that APP β-CTF causes synaptic toxicity in neurons through an endosome pathway, independent of Aβ or amyloid plaques.
eLife · Apr 23, 2025Peer-reviewedNeuroscience