Author

Yelin Chen

Chinese Academy of SciencesORCID 0000-0002-9793-2941Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Aaron D. GitleriD· 1 shared Agessandro AbrahãoiD· 1 shared Ang LiiD· 1 shared Cailu Sun· 1 shared Chaoying FuiD· 1 shared Chenfang SiiD· 1 shared Ekaterina A. RogaevaiD· 1 shared Helei Lei· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBioinformatics

Aaron D. GitlerORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJun 28, 2025

Spliformer-V2 enables multi-tissue prediction and interpretation of splice-altering genetic variants

Tang Xuelin, Meiyu Shao, Helei Lei…·Ming Zhang

Spliformer-V2 predicts and interprets tissue-specific effects of splice-altering variants, identifying disease-relevant genes and therapeutic targets in ALS.

1 citation

humanwhole-genome sequencing

NeuroscienceeLifePeer-reviewedApr 23, 2025

APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ

Mengxun Luo, Jia Zhou, Cailu Sun…·Yelin Chen

This study shows that APP β-CTF causes synaptic toxicity in neurons through an endosome pathway, independent of Aβ or amyloid plaques.

2 citations

mouseproteomics

NeuroscienceThe Journal of Cell BiologyPeer-reviewedOct 5, 2021

CHMP2B regulates TDP-43 phosphorylation and proteotoxicity via modulating CK1 turnover independent of the autophagy-lysosomal pathway

Xue Deng, Xing Sun, Wenkai Yue…·Yanshan Fang

This study identifies CHMP2B as a regulator of TDP-43 phosphorylation and proteotoxicity through CK1 turnover, independent of autophagy-lysosomal pathways in neurodegenerative diseases.

27 citations

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