Yaoyang Zhang

This study identifies a postsynaptic TAK1-GluN2B signaling axis that maintains synaptic integrity and cognitive function, with reduced TAK1 levels contributing to age-related hippocampal decline.

This study shows that APP β-CTF causes synaptic toxicity in neurons through an endosome pathway, independent of Aβ or amyloid plaques.

This study identifies CDK12 condensates at nuclear speckles as a therapeutic target and demonstrates that cyclin K molecular glue degraders like HQY1428 disrupt these condensates, inhibiting oncogenic transcription and ovarian cancer growth.

The paper develops a secretome profiling method for astrocytes and identifies proteins involved in disease-related toxicity and neuroprotection.

This study shows that N-acetylation of α-synuclein enhances its ability to cluster synaptic vesicles via increased interaction with lysophosphatidylcholine.

The paper develops Quartet, a proteome reference material with built-in truths, to assess label-free proteomics reproducibility across platforms and labs.

The paper constructs a hybrid spectral library combining DIA-MS data and a targeted virtual library to enhance proteome coverage, achieving significant increases in protein and peptide identification in mouse brain tissues.

This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.

This study shows that aging causes H3K27me3 drift, reducing glycolytic gene expression and lifespan, while PRCs-deficiency or glycolytic gene increase improves longevity.