Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer.
Tamara McErlain, Morgan J. Glass, Elizabeth C. McCulla, Caitlin A Madden, Lauren E. Hillers‐Ziemer, Kirsten E. Overdahl, Alan K. Jarmusch, Michael J. Kruhlak, Alexander Theodore Chesler, Howard Hua Yang, Maxwell P. Lee, Cristina M. Branco, Meera Murgai
This study shows pericyte-tumor interactions promote metastatic tumor cell dormancy via PIEZO1-mediated lysophospholipid transfer, enhancing persistence and relapse risk.
bioRxiv · Feb 15, 2025 · PreprintCancer Biology