Howard Hua Yang

This study shows that c-Myc protein stability determines the response of Ras-mutant multiple myeloma cells to RAS and MEK inhibitors, suggesting direct RAS targeting is more effective.

This study shows cancer stem cells (CSCs) have distinct population dynamics and are hyper-responsive to microenvironmental cues, which regulate metastasis and therapy response via the YAP/TAZ/TEAD pathway.

This study shows pericyte-tumor interactions promote metastatic tumor cell dormancy via PIEZO1-mediated lysophospholipid transfer, enhancing persistence and relapse risk.

This paper introduces a deep learning framework, REGLE, that improves genomic discovery and risk prediction for respiratory and circulatory diseases by learning low-dimensional embeddings from high-dimensional clinical data.

This paper introduces M-REGLE, a multimodal deep learning method that improves genetic analysis of cardiovascular traits by integrating multiple clinical data modalities and outperforms unimodal approaches in locus discovery and risk prediction.

The paper evaluates variant calling in difficult genomic regions using short- and long-read sequencing, showing improved performance with new methods and multi-technology approaches.

DeepConsensus improves PacBio HiFi read accuracy and assembly quality using a gap-aware transformer model.

The paper provides a dataset of 9 gold-standard samples sequenced on multiple platforms and protocols to benchmark sequencing and analysis methods.