Maxwell P. Lee

This study shows cancer stem cells (CSCs) have distinct population dynamics and are hyper-responsive to microenvironmental cues, which regulate metastasis and therapy response via the YAP/TAZ/TEAD pathway.

This study shows pericyte-tumor interactions promote metastatic tumor cell dormancy via PIEZO1-mediated lysophospholipid transfer, enhancing persistence and relapse risk.

This study develops mouse models of brain metastatic melanoma to identify immune and molecular factors influencing response to immunotherapy.

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

Trisicell infers subclonal expansion patterns and therapeutic impact of intratumor heterogeneity from scRNAseq data, revealing correlations between mutational composition and tumor aggressiveness.

PhISCS-BnB computes the most likely perfect tumor phylogeny from single-cell sequencing data, offering optimality guarantees and significant speed improvements over existing methods.