De novo design of Ras isoform selective binders
Jason Z. Zhang, Xinting Li, Alexa Rane Batingana, Caixuan Liu, Hanlun Jiang, Kevin Shannon, Benjamin J. Huang, Kejia Wu, David A. Baker
This study designs Ras isoform-specific binders using deep learning to target the C-termini of Ras proteins, enabling specific inhibition and study of their roles in biology and disease.
Cell chemical biology · Mar 1, 2026Peer-reviewedBioengineering