Caixuan Liu

This study investigates how LCA-linked mutations in TRiC/CCT subunit CCT2 disrupt its allosteric network and functional cycle, leading to structural and functional defects associated with Leber Congenital Amaurosis.

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

This study uses cryo-EM to reveal conformational dynamics of SARS-CoV-2 spike trimer in complex with ACE2, showing how ACE2 binding triggers structural changes and enhanced infectivity.