Neutrophil-microglia interaction drives reversible motor dysfunction in neuromyelitis optica model induced by subarachnoid AQP4-IgG
Fangfang Qi, Vanda A. Lennon, Shunyi Zhao, Yong Guo, Husheng Ding, Caiyun Liu, Whitney M. Bartley, Tingjun Chen, Claudia Francesca Lucchinetti, Long-jun Wu
The paper shows that neutrophil-derived C5a signaling through microglial C5aR1 drives reversible motor dysfunction in a mouse NMO model induced by AQP4-IgG.
Journal of Clinical Investigation · Feb 10, 2026Peer-reviewedNeuroscience