Shunyi Zhao

The paper identifies astrocyte-to-microglia purinergic signaling as a mechanism converting neuronal hypoactivity into synapse-selective microglial regulation of circuit activity.

The paper shows that neutrophil-derived C5a signaling through microglial C5aR1 drives reversible motor dysfunction in a mouse NMO model induced by AQP4-IgG.

This study shows that microglia interact with noradrenergic axons in the frontal cortex, enhancing norepinephrine transmission and supporting wakefulness.

This study identifies satellite microglia in adult mice that modulate inhibitory synapses and neuronal activity by physically shielding inhibitory connections.

This study shows that activating microglial Gi signaling reduces microglial activity and disrupts neuronal synchronization.

The paper shows that impaired microglial phagocytosis due to TREM2 deficiency promotes seizure development in mice and correlates with seizure history in human patients.

This study shows that reducing Hv1 proton channels in macrophages improves antigen presentation and anti-tumor responses in glioma by altering macrophage behavior and immune response.

The paper identifies rod-shaped microglia in a TDP-43 mouse model that interact with neuronal dendrites to reduce cortical hyperexcitability and protect against neurodegeneration.

The paper identifies UDP-P2Y6 signaling as a key driver of microglial calcium activity, phagocytosis, and neuroinflammation during epileptogenesis.

The paper shows that higher TREM2 expression in gliomas correlates with poor prognosis, but TREM2 deficiency does not improve outcomes in pre-clinical models, as it impairs myeloid cell phagocytosis and MHCII-dependent CD4+ T cell responses.

This study uses chemogenetic manipulation to show that microglia have both seizure-reducing and seizure-promoting effects in a mouse epilepsy model.

This study identifies a novel interaction between TREM2 and TDP-43, showing TREM2 mediates microglial neuroprotection against TDP-43-related neurodegeneration.