Fangfang Qi

This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.

The paper shows that neutrophil-derived C5a signaling through microglial C5aR1 drives reversible motor dysfunction in a mouse NMO model induced by AQP4-IgG.

This study shows that microglia interact with noradrenergic axons in the frontal cortex, enhancing norepinephrine transmission and supporting wakefulness.

This study identifies satellite microglia in adult mice that modulate inhibitory synapses and neuronal activity by physically shielding inhibitory connections.

This study shows maternal SARS-CoV-2 vaccination increases hippocampal neurogenesis and working memory in offspring mice via IFN-gamma responsive microglia.

This study shows that activating microglial Gi signaling reduces microglial activity and disrupts neuronal synchronization.

The paper identifies rod-shaped microglia in a TDP-43 mouse model that interact with neuronal dendrites to reduce cortical hyperexcitability and protect against neurodegeneration.

The paper shows that higher TREM2 expression in gliomas correlates with poor prognosis, but TREM2 deficiency does not improve outcomes in pre-clinical models, as it impairs myeloid cell phagocytosis and MHCII-dependent CD4+ T cell responses.

This study shows that repeated nasal BCG exposure accelerates dural lymphatics development in neonatal mice, especially when combined with intracutaneous BCG injection.

This study shows that transferring BCG-induced T lymphocytes into immune-deficient mice increases hippocampal cell proliferation and reduces anxiety-like behavior.