Intellectual disability risk gene RFX4 regulates cortical neurogenesis by restraining neuronal differentiation
Julianna J. Determan, Gareth Chapman, Sydney R. Crump, Faiza Batool, Sofia Malik, Taranjit S. Gujral, William Buchser, Caleb Valentine, Serena N Elia, Monica F. Sentmanat, Xiaoxia Cui, Haley Jetter, Kristen L. Kroll
This study identifies RFX4's role in cortical development by showing it restrains neurogenesis and regulates synaptic gene expression, with distinct effects from haploinsufficiency.
bioRxiv · Feb 17, 2026 · PreprintDevelopmental Biology