Gareth Chapman

Intellectual disability risk gene RFX4 regulates cortical neurogenesis by restraining neuronal differentiation

This study identifies RFX4's role in cortical development by showing it restrains neurogenesis and regulates synaptic gene expression, with distinct effects from haploinsufficiency.

Tatton-Brown-Rahman-Syndrome-associated DNMT3A mutations de-repress cortical interneuron differentiation to disrupt neuronal network function

This study shows that DNMT3A mutations in TBRS disrupt cortical interneuron differentiation, leading to neuronal network dysfunction and contributing to intellectual disability and autism.

Autism and Intellectual Disability-Associated MYT1L Mutation Alters Human Cortical Interneuron Differentiation, Maturation, and Physiology

This study examines how pathogenic MYT1L mutations affect human cortical interneuron differentiation, maturation, and physiology using stem cell models.

DLG2 knockout reveals neurogenic transcriptional programs underlying neuropsychiatric disorders and cognition

This study identifies neurogenic transcriptional programs linked to neuropsychiatric disorders and cognition using DLG2 knockout models and transcriptomic data.

Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome.

This study investigates the effects of 1q21.1 deletion and duplication on neuronal development using induced pluripotent stem cells and shows reciprocal phenotypes and potential therapeutic targets.