Kristen L. Kroll

This study characterizes MYT1L-Related Neurodevelopmental Disorder using data from the Brain Gene Registry, identifying cognitive, behavioral, and clinical features in affected individuals.

This study identifies RFX4's role in cortical development by showing it restrains neurogenesis and regulates synaptic gene expression, with distinct effects from haploinsufficiency.

This study examines the molecular and behavioral effects of MYT1L haploinsufficiency in mice, finding region-specific hypothalamic disruptions and sex-specific behavioral stability.

The paper shows a single binge ethanol exposure rapidly increases apoptosis in early adolescent and adult mice, with Myt1l haploinsufficiency modulating this effect across developmental stages.

This study shows that DNMT3A mutations in TBRS disrupt cortical interneuron differentiation, leading to neuronal network dysfunction and contributing to intellectual disability and autism.

This study examines how pathogenic MYT1L mutations affect human cortical interneuron differentiation, maturation, and physiology using stem cell models.

This study examines the effects of Myt1l heterozygous mutation on lifespan and health in mice, finding no significant difference in lifespan or end-of-life histopathology compared to wildtype mice.

This study uses iPSC models to show that a 15q13.3 duplication causes distinct neurodevelopmental and functional anomalies in an affected individual but not their unaffected mother, while both share increased cholinergic activity.

This paper identifies Geminin as a regulator of Hox gene expression in mouse limb development, showing its role in patterning limb skeletal elements through effects on Hox gene expansion and SHH signaling.

This study models multiplex autism using iPSC-derived neurons from a family with varying ASD liability, identifying morphological, physiological, and transcriptomic changes linked to polygenic susceptibility.