Cancer BiologyCell ReportsPeer-reviewed
Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation
Shilpa S. Dhar, Calena J. Brown, Ali Rizvi…·Min Gyu Lee
This study shows that heterozygous Kmt2d loss promotes medulloblastoma by enhancing tumor-promoting programs and that combining LSD1 inhibition with oxidative phosphorylation blockade reduces tumorigenicity.